5-Bromo-7-nitroindoline 5-Bromo-7-nitro-2,3-dihydroindole in stock Factory
5-Bromo-7-nitroindoline
CAS: 80166-90-1
Molecular Formula: C8H7BrN2O2
5-Bromo-7-nitroindoline 5-Bromo-7-nitro-2,3-dihydroindole in stock Factory - Names and Identifiers
| Name | 5-Bromo-7-nitroindoline |
| Synonyms | Einecs 279-411-4 5-BroMo-7-Niteoindoline 5-BROMO-7-NITROINDOLINE 5-Bromo-7-nitroindoline 5-BROMO-7-NITRO-2,3-DIHYDROINDOLE 5-Bromo-7-nitro-2,3-dihydro-1H-indole 5-Bromo-7-Nitro-2,3-dihydro-1H-indole 1H-Indole, 5-broMo-2,3-dihydro-7-nitro- 5-Bromo-7-nitroindoline 5-Bromo-7-nitro-2,3-dihydroindole in stock Factory |
| CAS | 80166-90-1 |
| EINECS | 279-411-4 |
| InChI | InChI=1/C8H7BrN2O2/c9-6-3-5-1-2-10-8(5)7(4-6)11(12)13/h3-4,10H,1-2H2 |
5-Bromo-7-nitroindoline 5-Bromo-7-nitro-2,3-dihydroindole in stock Factory - Physico-chemical Properties
| Molecular Formula | C8H7BrN2O2 |
| Molar Mass | 243.06 |
| Density | 1.704±0.06 g/cm3(Predicted) |
| Melting Point | 133-136°C |
| Boling Point | 344.2±42.0 °C(Predicted) |
| Flash Point | 162°C |
| Water Solubility | Insoluble in water. |
| Vapor Presure | 6.67E-05mmHg at 25°C |
| BRN | 1373199 |
| pKa | -1.87±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.64 |
| MDL | MFCD00005708 |
5-Bromo-7-nitroindoline 5-Bromo-7-nitro-2,3-dihydroindole in stock Factory - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Class | IRRITANT |
| Packing Group | III |
5-Bromo-7-nitroindoline 5-Bromo-7-nitro-2,3-dihydroindole in stock Factory - Reference Information
| trait | light yellow crystals |
| preparation | studies on the synthesis of indole compounds and the improvement of methods are constantly reported. According to literature reports, there are mainly Fischer synthesis method, L-B synthesis method, Reissert method, "indole-indoline-indole and other methods. Fischer synthesis method is suitable for the synthesis of pyrrole ring substituted indole derivatives, L-B synthesis method is suitable for the synthesis of benzene ring substituted indole derivatives, Reissert method is the preferred method for the synthesis of 2-substituted indole, the "indole-indoline-indole" step synthesis method can be simple, mild preparation of 5-substituted indole compounds. In this paper, 5-bromo-7-nitroindoline was synthesized from indole by the "indole-indoline-indole" procedure. 5-bromo-7-nitroindoline synthesis reaction formula as shown below: Figure 1 5-bromo-7-nitroindoline synthesis reaction formula experimental operation: 5-bromo-7-nitroindole, water and aluminum trichloride were added to the reactor, heated to reflux, zinc powder was added in portions, the reaction was stirred under reflux, and the reaction was monitored by thin layer chromatography (developing solvent: V (petroleum ether):V (ethyl acetate) = 4. 1, Qingdao marine thin layer chromatography silica gel plate);5 hours reaction is complete, filtration, remove excess zinc powder, filtrate with sodium hydroxide solution to pH 8, ether extraction 3 times, ether layer in turn with water, saturated brine washing, anhydrous sodium sulfate drying, filtration, distillation, light yellow crystals 5-bromo-7-nitroindoline. |
Last Update：2024-04-09 15:16:53
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